www.ronZnet.com
Ronald Zuckermann, Ph.D.


Nanobioscience Research
at the intersection of Chemistry, Biology & Engineering

Specializing in:
  • Molecular biomimicry with bio-inspired polymers
  • Combinatorial chemistry
  • Solid-phase synthesis
  • Peptoids and non-natural oligomers
  • Self-assembly and folding of protein-mimetic polymers
  • Laboratory automation
  • Custom instrumentation
  • Mechanical engineering & Fluidics



Contact Information

Ronald Zuckermann, Ph.D.
Biological Nanostructures Facility
The Molecular Foundry
Lawrence Berekeley National Laboratory
1 Cyclotron Rd., MS 67-5110
Berkeley, CA 94530

Phone: (510) 387-9364
E-mail: ron@ronznet.com



About Ron

Ronald Zuckermann received his B.S. in Chemistry in 1984 from Harvey Mudd College where he did undergraduate research in synthetic organic chemistry.  He then went on to UC Berkeley to study Bioorganic Chemistry with Dr. Peter Schultz.  His thesis work was on the synthesis of semi-synthetic nucleases capable of the sequence-specific cleavage of RNA.  After receiving the first Schultz group Ph.D. in 1989, he became one of the founding chemists at Protos Corp., a combinatorial drug discovery start-up in Emeryville, CA.  There he helped develop several key drug discovery technologies such as robotic combinatorial library synthesizers, affinity selection methods and a novel class of heteropolymers called "Peptoids".  Chiron Corp. acquired Protos in 1991 where this work continued and was applied to small molecule drug discovery, new biomaterials and DNA delivery.  Dr. Zuckermann was promoted to Research Fellow in 2003. In early 2006, he left Chiron to join the Lawrence Berkeley National Laboratory, where he is currently Facility Director of the Biological Nanostructures Facility at The Molecular Foundry. There he is expanding the application of peptoid polymers to mimic the structure and function of proteins, by folding peptoid chains into defined nanoarchitectures. He was promoted to Senior Scientist in 2011. He has published over 115 papers and is co-inventor on 38 patents.




What's Hot!

May 2003



RZ receives Chiron Research Fellow Award at all employee meeting from Craig Wheeler.
Audio capture
(mp3, 7:39).

May 2007

Interview in Nano World News:

"Techniques for Rapid Drug Discovery Now Focusing on Nanoscience Research"

May 2008

Feature story in LBNL News Center:

"A Tailorable Nanotube, Formed by a Ring-shaped Protein"

July 2008

Feature story in LBNL News Center:

"Nano-Sized Jaws Perform Like Proteins"

August 7-8th, 2008

The 6th Peptoid Summit was held on at the Molecular Foundry.

December 1, 2008

Eric Drexler's blog on MetaModern:

"Peptoids at the Molecular Foundry"

August 9-10th, 2010

The 7th Peptoid Summit was held at the Molecular Foundry

April 2010

Feature story in LBNL News Center about our discovery of peptoid nanosheets:

"Berkeley Lab Scientists Create ‘Molecular Paper’"

April 12, 2010

Wired Science at WIRED.com:

"Floating Nanosheets Could Be the Plywood of Nanotechnology"

April 19, 2010

News of the Week story at Chemical & Engineering News about our first paper on peptoid nanosheets:

"Bioinspired Material Debuts"

April 22, 2010

Eric Drexler's blog on MetaModern:

"Peptoid nanosheets: A platform for new nanotechnologies"

April 28, 2010

Kristin Brinner's blog at ScienceBlog.com:

"Tasty New Molecular Sandwiches"

June 22, 2010

Guest blog by RZ on ScriptPhD.com about my long-term quest to make protein like materials from non-natural building blocks:

"Beauty and the Building Blocks"

January 18, 2011

Feature story in LBNL News Center on a peptoid block copolymer that forms nanosheets that roll up into superhelices:

"A Nanoscale Rope"

August 2011

Award-winning lecture presented at the 2011 Annual Retreat of the LBNL Materials Sciences Division

"Perspective: Safety Culture"
Lecture slides: PDF or Keynote format. (e-mail me if you have comments!)

Profile in Safety story about my safety management philosophy in "Today at LBNL"

September 2011

Top story in the Dept. of Energy's Energy Frontier Research Newsletter about our work on peptoids that accelerate the mineralization of CO2:

"Turning Greenhouse Gas to Stone"

September 2011

Special issue of Biopolymers Peptide Science devoted to papers presented at the 7th Peptoid Summit:

7th Peptoid Summit Special Issue

 

October 17, 2011

Feature story in LBNL News Center about our JACS paper on how peptoid nanosheets are formed:

"Shaken, not Stirred"

Original article in press at J. Am. Chem. Soc.

October 17, 2011

Science Concentrate in Chemical & Engineering News

"Surprise Route to Peptoid Nanosheets"

pdf version: here.

November 2, 2011

Journal of Visualized Experiments published a detailed 14 minute video and accompanying written protocol on how to make peptoids and self assemble them into nanosheets. Now anyone can get involved!

"Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets"

See a 1 min preview here!

 

August 2012

8PS logo

The 8th peptoid Summit was held in Berkeley on August 9-10, 2012

August 21, 2012

LBNL press release about our PNAS paper on peptoid structure prediction:

pnas authors

"Form, Function and Folding"

See also:
Feature article on DOE's Office of Science website: "Predictions, proteins and peptoids"

May 13, 2013

Ron delivers his "Big Idea" at an LBNL Science at the Theater event at the Berkeley Repertory Theater:

SAT

Link to video here.

July 29, 2013

Peppytides paper published in PNAS on our foldable, physical model of the polypeptide chain.

helix

Peppytides.com website launched to help you build your own 3D-printed protein!

August 26, 2013

The Berkeley Science Journal featured a really nice blog posting on our Peppytide models.

promita

Peppytides: Molecular Models of the Future

August 2013

Ron wins the Lawrence Berkeley National Laboratory Director's Award for Excellence in Safety!

Ron and Paul

October 30, 2013

LBNL press release on our ACS Nano paper on antibody-mimetic peptoid nanosheets.

group_shot

“Molecular Velcro” May Lead to Cost-Effective Alternatives to Natural Antibodies

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Also, hear an 8-minute interview with Ron about this paper in the October edition of the ACS Nano Podcast (see episode #75).

January 7, 2014

Make Magazine publishes a project tutorial on how to make your own Peppytide models.

Make

Make: Projects
"Peppytides"

Build a super accurate, scaled 3D-model of a polypeptide chain that can be folded into all the basic protein structures, like α-helices, β-sheets, and β-turns. The model, called a Peppytide, is made by linking together many 3D-printed molecular subunits with a series of precisely placed magnets and screws. Once built, the Peppytide chain faithfully reproduces the size, shape and flexibility of proteins... read more!

January 20, 2014

Berkeley Lab releases a cool 5 minute video on the Peppytide project!

still1

still3

still3

Peppytides: Interactive Models of Polypeptide Chains

April, 19, 2014

Ron delivers one of the
2014 HC Brown Symposium
lectures in Organic Chemistry at Purdue University.

Brown

Speakers and hosts. Front row (L to R): Mingji Dai (Purdue), John Hartwig (UC Berkeley), Sam Stupp (Northwestern), Ron Zuckermann (LBNL), Dave Tirrell (Caltech), Stephen Martin (UT Austin), Tim Swager (MIT). Back row (L to R): Tim Warren, Mark Lipton, David Thompson, Chris Uyeda, Alex Wei.

Plaque

September 2, 2014

Our paper on the assembly of peptoid nanosheets at the oil-water interface came out in PNAS.

PNAS_authors

LBNL press release:
"Peptoid Nanosheets at the Oil/Water Interface"

University of Oregon story:
"UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique"


September 4, 2014

Ron and Promita were awarded the LBNL Director's Award for Exceptional Achievement in outreach for our work on the Peppytide molecular models!

Ron_promita

 

November 4, 2014

9th Peptoid Summit announced!

Come join us at the 9th Peptoid Summit, August 6-7th, 2015, Molecular Foundry, Berkeley, CA.

9PS_logo

 

December 11, 2014

Ron's research on peptoid nanosheets highlighted in Today at Berkeley Lab.

"Mimicking Nature for Homeland Security"

RZ_Prelude

   

 

Videos!

 
 
 

 

 

 
 

Pictures!