Ronald Zuckermann, Ph.D.

Journal Cover gallery: click on cover to enlarge

JCC_cover JDR_cover Adv_Mat_cover JOC_horse
ACR Chem_comm cover_45 cover_46
Bolt_Med LogD_cover    

Publications at a glance

Reviews/Book Chapters

J. Am. Chem. Soc.


Proc. Natl. Acad. Sci. U.S.A.
Peptide Science
ACS Nano
J. Org. Chem.
Chem. Biol.
Chem. Commun.
J. Comb. Chem.
Soft Matter
Nature Materials
Nature 1


Word cloud from all paper titles (1983 - 2016)

Publication list by year

Google Scholar Citation analysis here.

Lawrence Berkeley National Laboratory (2006 - present)

LBL_logo MF logo

pdf 141. Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers.
Guseva, E.; Zuckermann, R.N.; Dill, K.A., Proc. Natl. Acad. Sci. U. S. A., 114, E7460-E7468 (2017).
Supporting info (pdf)

Times Beacon Record:
Ken Dill depicts prehistoric pre-protein process

The Statesman:
Researchers propose mechanism to help explain origin of life

pdf 140. Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils.
Wang, S.-T.; Lin, Y.; Spencer, R.K.; Thomas, M.R.; Nguyen, A.I.; Amdursky, N.; Pashuck, E.T.; Skaalure, S.C.; Song, C.Y.; Parmar, P.A.; Morgan, R.M.; Ercius, P.; Aloni, S.; Zuckermann, R.N.; Stevens, M.M., ACS Nano,  ASAP online (2017).
Supporting Info (pdf)
pdf 139. Morphology-Driven Control of Metabolite Selectivity Using Nanostructure-Initiator Mass Spectrometry.
Gao, J.; Louie, K.B.; Steinke, P.; Bowen, B.P.; Raad, M.d.; Zuckermann, R.N.; Siuzdak, G.; Northen, T.R., Analytical Chemistry, 89, 6521-6526 (2017).
Supporting Info (pdf)
PepSci 138. Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids.
Bolt, H.L.; Williams, C.E.J.; Brooks, R.V.; Zuckermann, R.N.; Cobb, S.L.; Bromley, E.H.C., Peptide Science, 108, e23014 (2017).
Supporting Info (docx)
Med_icon 137. Exploring the links between peptoid antibacterial activity and toxicity.
Bolt, H.L.; Eggimann, G.A.; Jahoda, C.A.B.; Zuckermann, R.N.; Sharples, G.J.; Cobb, S.L., MedChemComm, 8, 886-896 (2017).
pdf 136.

Role of Backbone Chemistry and Monomer Sequence in Amphiphilic Oligopeptide- and Oligopeptoid-Functionalized PDMS- and PEO- Based Block Copolymers for Marine Antifouling and Fouling Release Coatings.
Patterson, A.L.; Wenning, B.; Rizis, G.; Calabrese, D.R.; Finlay, J.A.; Franco, S.C.; Zuckermann, R.N.; Clare, A.S.; Kramer, E.J.; Ober, C.K.; Segalman, R.A., Macromolecules, 50, 2656-2667 (2017).
Supporting Info (pdf)

pdf 135.

Oxygen K Edge Scattering from Bulk Comb Diblock Copolymer Reveals Extended, Ordered Backbones above Lamellar Order–Disorder Transition. 
Kortright, J.B.; Sun, J.; Spencer, R.K.; Jiang, X.;Zuckermann, R.N., J. Phys. Chem. B,  121, 298-305 (2017).
Supporting Info (pdf)



cover_45 134.

Molecular Engineering of the Peptoid Nanosheet Hydrophobic Core. 
Robertson, E.J.; Proulx, C.; Su, J.K.; Garcia, R.L.; Yoo, S.; Nehls, E.M.; Connolly, M.D.; Taravati, L.; Zuckermann, R.N., Langmuir,  32, 11946-11957 (2016).
Supporting Info (pdf)
SI crystal structures (cif files)

engineering ACS Editor's Choice article
cover_46_icon 133. Structure–Rheology Relationship in Nanosheet-Forming Peptoid Monolayers. 
Robertson, E.J.; Nehls, E.M.; Zuckermann, R.N., Langmuir,  32, 12146-12158 (2016).
Supporting Info (pdf)
pdf 132.

Morphology Study of Phosphonated Peptoid Block Copolymer.
Jiang, X.; Sun, J.; Zuckermann, R.; Downing, K.H.; Balsara, N., Microscopy and Microanalysis, 22, 1926-1927 (2016).
Link to website

pdf 131. On-Resin N-Terminal Peptoid Degradation: Toward Mild Sequencing Conditions.
Proulx, C.; Noë, F.; Yoo, S.; Connolly, M.D.; Zuckermann, R.N., Pept.Sci., 106, 726-736 (2016).
Supporting Info (docx)
pdf 130. Surface-Directed Assembly of Sequence-Defined Synthetic Polymers into Networks of Hexagonally Patterned Nanoribbons with Controlled Functionalities.
Chen, C.-L.; Zuckermann, R.N.; DeYoreo, J.J., ACS Nano, 10, 5314-5320 (2016).
Supporting Info (pdf)
pdf 129.

Implicit-solvent coarse-grained simulation with a fluctuating interface reveals a molecular mechanism for peptoid monolayer buckling.
Haxton, T.K.; Zuckermann, R.N.; Whitelam, S. J. Chem. Theory Comput., 12, 345–352 (2016).
Supporting Info (zip)

pdf 128.

Morphology and proton transport in humidified phosphonated peptoid block copolymers.
Sun, J.; Jiang, X.; Siegmund, A.; Connolly, M.D.; Downing, K.H.; Balsara, N.P.; Zuckermann, R.N., Macromolecules, 49, 3083–3090 (2016).
Supporting Info (pdf)

pdf 127.

Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles.
Sun, J.; Jiang, X.; Lund, R.; Downing, K.H.; Balsara, N.P.; Zuckermann, R.N., Proc. Natl. Acad. Sci. U.S.A., 113, 3954-3959 (2016).
Supporting Info (docx)
Movie S1
Movie S2


LBNL News Center:
Nature-Inspired Nanotubes That Assemble Themselves, With Precision

C&E News:
Polypeptoid self-assembles into nanotubes

Dept. of Energy:
Nature-Inspired Nanotubes that Assemble Themselves

chem_comm 126. Improved chemical and mechanical stability of peptoid nanosheets by photo-crosslinking the hydrophobic core.
Flood, D.; Proulx, C.; Robertson, E.J.; Battigelli, A.; Wang, S.; Schwartzberg, A.M.; Zuckermann, R.N., Chem. Commun., 52, 4753-4756 (2016).
Supporting Info (pdf)

pdf 125. Application of black silicon for nanostructure-initiator mass spectrometry.
Gao, J.; de Raad, M.; Bowen, B.P.; Zuckermann, R.N.; Northen, T.R.,
Analytical Chem., 88, 1625-1630 (2016).
Supporting Info (pdf)
ACR_icon 124.

Design, synthesis, assembly, and engineering of peptoid nanosheets.
Robertson, E.J.; Battigelli, A.; Proulx, C.; Mannige, R.V.; Haxton, T.K.; Yun, L.; Whitelam, S.; Zuckermann, R.N., Acc. Chem. Res., 49, 379-389 (2016).

confocal Review article



pdf 123.

Peptoid nanosheets exhibit a new secondary structure motif.
Mannige, R.V.; Haxton, T.K.; Proulx, C.; Robertson, E.J.; Battigelli, A.; Butterfoss, G.L.; Zuckermann, R.N.; Whitelam, S., Nature, 516, 415-420 (2015).
Supporting Info (pdf)
Nanosheet structure files (pdb format)


LBNL News Center:
Newly Discovered ‘Design Rule’ Brings Nature-Inspired Nanostructures One Step Closer

C&E News:
Peptoids Do a Double-Twist

Protein-mimetic polymer exhibits unique structure not seen in nature

Folding protein-mimetic shapes

JOC 122.

Accelerated Submonomer Solid-Phase Synthesis of Peptoids Incorporating Multiple Substituted N-Aryl Glycine Monomers.
Proulx, C.; Yoo, S.; Connolly, M.D; Zuckermann, R.N., J. Org. Chem., 80, 10490-10497 (2015).
Supporting Info (pdf)



Peptoid nanosheets as soluble, two-dimensional templates for calcium carbonate mineralization.
Jun, J.M.V.; Altoe, V.; Aloni, S.; Zuckermann, R.N., Chem. Commun., 51, 10218-10221 (2015).
Supporting Info (pdf)

pdf 120. Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides.
Mojsoska, B.; Zuckermann, R.N.; Jenssen, H., Antimicrob. Agents Chemother., 59, 4112-4120 (2015).

LBNL News Center:
"Using Robots at Berkeley Lab, Scientists Assemble Promising Antimicrobial Compounds"

Peptoids: The Next Generation of Antibiotics?

pdf 119. The Organic Flatland—Recent Advances in Synthetic 2D Organic Layers.
Cai, S.-L.; Zhang, W.-G.; Zuckermann, R.N.; Li, Z.-T.; Zhao, X.; Liu, Y., Adv. Mater., 38, 5762-5770 (2015).
2D Part of a special issue devoted to research at the Molecular Foundry
Adv_Mater 118.

Sequence Programmable Peptoid Polymers for Diverse Materials Applications.
Knight, A.S., Zhou, E.Y., Francis, M.B. and Zuckermann, R.N., Adv. Mater.,38, 5665–5691 (2015).


Review article,

Part of a special issue devoted to research at the Molecular Foundry

pdf 117.

Modeling Sequence-Specific Polymers Using Anisotropic Coarse-Grained Sites Allows Quantitative Comparison with Experiment.
Haxton, T.K.; Mannige, R.V.; Zuckermann, R.N.; Whitelam, S.W., J. Chem. Theory Comput., 11, 303-315 (2015).
Supporting Info (pdf)
MF-CG-TOID computer code (zip)



pdf 116.

Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets.
Sanii, B.; Haxton, T.K.; Olivier, G.K.; Cho, A.; Barton, B.; Proulx, C.; Whitelam, S.; Zuckermann, R.N., ACS Nano, 8, 11674-11684 (2014).
Supporting Info (pdf)

pdf 115. Morphology-Conductivity Relationship in Crystalline and Amorphous Sequence-Defined Peptoid Block Copolymer Electrolytes.
Sun, J.; Liao, X.; Minor, A.M.; Balsara, N.P.; Zuckermann, R.N., J. Am. Chem. Soc., 136, 14990-14997 (2014).
pdf 114. Precision sequence control in bioinspired peptoid polymers.
Sun, J.; Proulx, C.; Zuckermann, R.N., In Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties; ACS Symposium Series, Francois-Lutz, J., Ed. 1170, 25-53 (2014).
  Book chapter, review article
pdf 113.

Assembly and molecular order of two-dimensional peptoid nanosheets through the oil–water interface.
Robertson, E.J.; Olivier, G.K.; Qian, M.; Proulx, C.; Zuckermann, R.N.; Richmond, G.L., Proc. Natl. Acad. Sci. U.S.A., 111, 13284–13289 (2014).
Supporting Info (pdf)


LBNL press release:
"Peptoid Nanosheets at the Oil/Water Interface"

U. Oregon story:
"New nano-sized scaffolding technique"

JSTO in the News:
"Oil and Water is the Right Mix for Better
Chem-Bio Detection"

ALS Highlight:
"Peptoid Nanosheets offer a Diversity of Functionalities"

pdf 112. Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics.
Chen, C.-L.; Qi, J.; Tao, J.; Zuckermann, R.N.; DeYoreo, J.J., Sci. Reports, 4, 6266 (2014).
Supporting Info (pdf)
calcite PNNL research highlight:
"Inspired by Nature, Scientists Design Protein-esque Molecules to Lock Up Carbon Dioxide"
JDR_icon 111. Matching 4.7-Ĺ XRD spacing in Amelogenin Nanoribbons and Enamel Matrix.
Sanii, B.; Martinex-Avila, O.; Simpliciano, C.; Zuckermann, R.N.; Habelitz, S., J. Dent. Res., 93, 918-922 (2014).
pdf 110.

Sequence of Hydrophobic and Hydrophilic Residues in Amphiphilic Polymer Coatings Affects Surface Structure and Marine Antifouling/Fouling Release Properties.
van Zoelen, W.; Buss, H.G.; Ellebracht, N.C.; Lynd, N.A.; Fischer, D.A.; Finlay, J.; Hill, S.; Callow, M.E.; Callow, J.A.; Kramer, E.J.; Zuckermann, R.N.; Segalman, R.A., ACS Macro Letters, 3, 364 (2014).
Supporting Info (pdf)

pdf 109. Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: physical characterization and biological activity.
Konca, Y.U.; Kirshenbaum, K.; Zuckermann, R.N., Int. J. Nanomed., 9, 2271 (2014).


Development and Use of an Atomistic CHARMM-Based Forcefield for Peptoid Simulation.
Mirijanian, D.T.; Mannige, R.V.; Zuckermann, R.N.; Whitelam, S., J. Comput. Chem., 35, 360-370 (2014).
Supporting info (pdf)
Parameter file (inp file)
Topology file (inp file)

rama Featured in DoD blog: "Armed with Science"
pdf 107. Crystallization in Sequence-Defined Peptoid Diblock Copolymers Induced by Microphase Separation.
Sun, J.; Teran, A.A.; Liao, X.; Balsara, N.P.; Zuckermann, R.N., J. Am. Chem. Soc., 136, 2070-2077 (2014).
Supporting Info (pdf)



pdf 106. Nanoscale Phase Separation in Sequence-Defined Peptoid Diblock Copolymers.
Sun, J.; Teran, A.A.; Liao, X.; Balsara, N.P.; Zuckermann, R.N., J. Am. Chem. Soc., 135, 14119-14124 (2013).
Supporting Info (pdf)

pdf 105.

Antibody-Mimetic Peptoid Nanosheets for Molecular Recognition.
Olivier, G.K.; Cho, A.; Sanii, B.; Connolly, M.D.; Tran, H.; Zuckermann, R.N.
ACS Nano, 7, 9276-9386, (2013).
Supporting info.
DKP crystal structure (.cif file)

loop_sheet_icon LBNL press release:
Molecular Velcro


Coarse-grained, foldable, physical model of the polypeptide chain.
Chakraborty, P.; Zuckermann, R.N., Proc. Natl. Acad. Sci. U.S.A., 110, 13368-13373 (2013).

Supporting info:
Supplementary Information (pdf)
Dataset_S01.txt (STL file)
Dataset_S02.txt (STL file)
Dataset_S03.txt (STL file)
Chain_folding_movie (Quicktime .mov file)


visit Peppytides.com for more!

Also check out:
Make Tutorial,
LBNL video,
Berkeley Science Review blog.

pdf 103. Polypeptoids: a model system to study the effect of monomer sequence on polymer properties and self-assembly.
Rosales, A.M.; Segalman, R.A.; Zuckermann, R.N., Soft Matter, 9, 8400-8414 (2013).
protein Review article
pdf 102.

Peptoid Polymers: A Highly Designable Bioinspired Material.
Sun, J.; Zuckermann, R.N., ACS Nano, 7, 4715-4732, (2013).

Review article
pdf 101.

Persistence length of polyelectrolytes with precisely located charges.
Murnen, H.K.; Rosales, A.M.; Dobrynin, A.V.; Zuckermann, R.N.; Segalman, R.A., Soft Matter, 9, 90-98 (2013).
Supporting Info.

SM 2013 icon


pdf 100.

Synthesis and characterization of designed BMHP1-derived self-assembling peptides for tissue engineering applications.
Silva, D.; Natalello, A.; Sanii, B.; Vasita, R.; Saracino, G.; Zuckermann, R.N.; Doglia, S.M.; Gelain, F., Nanoscale, 5, 704-718 (2013).
Supporting Info.

silva icon  


pdf 99.

Structure - Conductivity Relationship for Peptoid-Based PEO-Mimetic Polymer Electrolytes.
Sun, J.; Stone, G.M.; Balsara, N.P.; Zuckermann, R.N., Macromolecules, 45, 5151-5156 (2012).
Supporting Info.

PEO mimetic icon


pdf 98.

Impact of Hydrophobic Sequence Patterning on the Coil-to-Globule Transition of Protein-like Polymers.
Murnen, H.K.; Khokhlov, A.R.; Khalatur, P.G.; Segalman, R.A.; Zuckermann, R.N., Macromolecules, 45, 5229-5236 (2012).
Supporting Info.

HP globule icon  
pdf 97.

Determination of the persistence length of helical and non-helical polypeptoids in solution.
Rosales, A.M.; Murnen, H.K.; Kline, S.R.; Zuckermann, R.N.; Segalman, R.A., Soft Matter, 8, 3673-3680 (2012).
Supporting Info.

persitence length icon  
pdf 96. Tunable Surface Properties from Sequence-Specific Polypeptoid-Polystyrene Block Copolymer Thin Films.
van Zoelen, W.; Zuckermann, R.N.; Segalman, R.A., Macromolecules, 45, 7072-7082 (2012).
pdf 95.

Tunable Phase Behavior of Polystyrene-Polypeptoid Block Copolymers.
Rosales, A.M.; McCulloch, B.L.; Zuckermann, R.N.; Segalman, Rachel A., Macromolecules, 45, 6027-6035 (2012).
Supporting Info.

pdf 94. De novo structure prediction and experimental characterization of folded peptoid oligomers.
Butterfoss, G.L; Yoo, B.; Jaworski, J.N.; Chorny, I.; Dill, K.A.; Zuckermann, R.N.; Bonneau, R.; Kirshenbaum, K.; Voelz, V.A., Proc. Natl. Acad. Sci. U.S.A., 109, 14320-14325 (2012).
Supporting Info.
Structure files.

LBNL press release:
"Form, Function and Folding"

Feature article on DOE's website: "Predictions, proteins and peptoids"


JACS cover icon 93.

Shaken, not stirred: Collapsing a peptoid monolayer to produce free-floating, stable nanosheets.
Sanii, B.; Kudirka, R.; Cho, A.; Venkateswaran, N.; Oliver, G.K.; Olson, A.M.; Tran, H.; Harada, R.M.; Tan, L.; Zuckermann, R.N., J. Am. Chem. Soc., 133, 20808-20815 (2011).
Supporting Info.
Supplementary Movie 1 (Sheets from shaken vial)
Supplementary Movie 2 (Sheets from rotated vial)
Supplementary Movie 3 (SheetRocker vial rotator instrument)

LBNL press release:
"Shaken, not Stirred"

C&E News:
"A surprise route to peptoid nanosheets"


pdf 92.

Protein Side-Chain Translocation Mutagenesis via Incoproration of Peptoid Residues.
Lee, B.-C.; Zuckermann, R.N., ACS Chem. Biol., 6, 1367-1374 (2011).

pdf 91.

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets.
Tran, H.; Gael, S.L.; Connolly, M.D.; Zuckermann, R.N., J. Vis. Exp., 57, e3373, (2011).
Online video (14 min).
DOI : 10.3791/3373

Video preview in "This month in JoVE" (1 min).
pdf 90.

Protein Mimicry with Bioinspired Peptoid Polymers.
Zuckermann, R.N. Proc. 22nd Amer. Pep. Symp., 174-175 (2011).


Peptoid Origins.
Zuckermann, R.N. Pept. Sci., 96, 545-555 (2011).

pdf 88. A Universal Method for Detection of Amyloidogenic Misfolded Proteins.
Yam, A.Y.; Wang, X.; Gao, C.; Connolly, M.D.; Zuckermann, R.N.; Bleua, T.; Halla, J.; Fedynyshyn, J.; Allauzen, S.; Peretz, D.; Salisbury, C.M., Biochem., 50, 4322-4329 (2011).
Supporting Info.

LBNL press release:
"Into the (Mis)fold"

pdf 87.

Peptoids - Synthesis, Characterization, and Nanostructures.
Seo, J.; Lee, B.-C.; Zuckermann, R.N., In: P. Ducheyne, K.E. Healy, D.W. Hutmacher, D.W. Grainger, C.J. Kirkpatrick (eds.) Comprehensive Biomaterials, 2011, vol. 2, pp. 53-76 Elsevier.

Book chapter, review article

Folding of a Single-Chain, Information-Rich Polypeptoid Sequence into a Highly-Ordered Nanosheet.
Kudirka, R.; Tran, H.; Sanii, B.; Nam, K.T.; Choi, P.H.; Venkateswaran, N.; Chen, R.; Whitelam, S.; Zuckermann, R.N., Pept. Sci., 96, 586-595 (2011).



BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications.
Gelain, F.; Silva, D.; Villa, O.; Taraballi, F.; Natalello, A.; Caprini, A.; Nam, K.T.; Zuckermann, R.N.; Doglia, S.M.; Vescovi, A., ACS Nano, 5, 1845-1859 (2011).
pdf 84.

Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3 Mineralization.
Chen, C.-L.; Qi, J.; Zuckermann, R.N.; DeYoreo, J.J., J. Am. Chem. Soc., 133, 5214-5217 (2011).
Supporing Info.

Top story in EFRC Newsletter:
"Turning Greenhouse Gas to Stone"


Stabilization of nanoparticles under biological assembly conditions using peptoids.
Robinson, D.B.; Buffleben, G.M.; Langham, M.E.; Zuckermann, R.N., Pept. Sci., 96, 669-678 (2011).



pdf 82.

AB40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer’s Disease.
Gao, C.M.; Yam, A.Y.; Wang, X.; Magdangal, E.; Salisbury, C.; Peretz, D.; Zuckermann, R.N.; Connolly, M.D.; Hansson, O.; Minthon. L.; Zetterberg, H.; Blennow, K.; Fedynyshyn, J.P.; Allauzen, S., PLoS ONE, 5, e15725 (2010).

pdf 81.

Hierarchical Self-Assembly of a Biomimetic Diblock Copolypeptoid into Homochiral Super Helices.
Murnen, H.K.; Rosales, A.M.; Jaworski, J.N.; Segalman, R.A.; Zuckermann, R.N., J. Am. Chem. Soc., 132, 16112-16119 (2010).
Supporting Info.

LBNL press release:
"A Nanoscale Rope"
pdf 80.

Control of Crystallization and Melting Behavior in Sequence Specific Polypeptoids.
Rosales, A.M.; Murnen, H.K.; Zuckermann, R.N.; Segalman, R.A., Macromolecules, 43, 5627-5636 (2010).
Supporting Info.

pdf 79.

Free-floating ultra-thin two-dimensional crystals from sequence-specific peptoid polymers.
Nam, K.T.; Shelby, S.A.; Marciel, A.B.; Choi, P.C.; Chen, R.; Tan, L.; Chu, T.K.; Mesch, R.A.; Lee, B.-C.; Connolly, M.D.; Kisielowski, C.; Zuckermann, R.N. Nature Mater., 9, 454-460 (2010).
Supporting Info.
Supplementary Movie S1.


LBNL press release:
"Berkeley Lab Scientists Create ‘Molecular Paper’"

C&E News:
"A Bioinspird Material Debuts"

"Floating Nanosheets Could Be the Plywood of Nanotechnology"

pdf 78. Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami.
Ding, B.; Deng, Z.; Yan, H.; Cabrini, S.; Zuckermann, R.N.; Bokor, J., J. Am. Chem. Soc., 132, 3248-3249 (2010).
Supporting Info.
pdf 77.

Templated display of biomolecules and inorganic nanoparticles by metal ion-induced peptide nanofibers.
Lee, B.-C.; Zuckermann, R.N., Chem. Comm., 46, 1634-1636 (2010).
Supporting Info.

pdf 76.

Novel Peptoid Building Blocks: Synthesis of Functionalized Aromatic Helix-Inducing Submonomers.
Seo, J.; Barron, A.E.; Zuckermann, R.N., Org. Lett. 12, 492-495 (2010).
Supporting Info.

pdf 75.

Rapid Multistep Synthesis of a Bioactive Peptidomimetic Oligomer for the Undergraduate Laboratory.
Utku, Y.; Rohatgi, A.; Yoo, B.; Kirshenbaum, K.; Zuckermann, R.N.; Pohl, N.L., J. Chem. Ed. 87, 637-639 (2010).



4 74.

High-Throughput Sequencing of Peptoids and Peptide−Peptoid Hybrids by Partial Edman Degradation and Mass Spectrometry.
Thakkar, A.; Cohen, A.S.; Connolly, M.D.; Zuckermann, R.N.; Pei, D., J. Comb. Chem. 11, 294-302 (2009).
Supporting Info.

3 73. DNA directed assembly of nanoparticle linear structure for nanophotonics.
Ding, B.; Cabrini, S.; Zuckermann, R.N.; Bokor, J., J. Vac. Sci. Technol. B, 27, 184-187 (2009).
3 72.

Peptoids as Potential Therapeutics.
Zuckermann, R.N.; Kodadek, T., Curr. Op. Mol. Ther. 11, 299-307 (2009).

3 71. Close mimicry of lung surfactant protein B by "clicked" dimers of helical, cationic peptoids.
Dohm, M.T.; Seurynck-Servoss, S.L.; Seo, J.; Zuckermann, R.N.; Barron, A.E., Peptide Sci. 92, 538-553 (2009).
Supporting Info.



Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer.
Lee, B.-C.; Chu, T.K.; Dill, K.A.; Zuckermann, R.N., J. Am. Chem. Soc. 130, 8847-8855 (2008). Supporting info.

69. Intranasal administration delivers peptoids to the rat central nervous system.
Ross, T.M.; Zuckermann, R.N.; Reinhard, C.; Frey, W.H., Neuroscience Letters, 439, 30-33, (2008).
68. In vitro self-assembly of tailorable nanotubes from a simple protein building block.
Ballister, E.R.; Lai, A.H.; Zuckermann, R.N.; Cheng, Y.; Mougous, J.D., Proc. Natl. Acad. Sci. U. S. A. 105, 3733-3738 (2008).
67. Peptoids that mimic the structure, function and mechanism of helical antimicrobial peptides.
Chongsiriwatana, N.P.; Patch, J.A.; Czyzewski, A.M.; Dohm, M.T.; Ivankin, A.; Gidalevitz, D.; Zuckermann, R.N.; Barron, A.E., Proc. Natl. Acad. Sci. U. S. A. 105, 2794-2799 (2008).


Bio-inspired Polymers for Nanoscience Research.
Lee, B.-C.; Connolly, M. D.; Zuckermann, R. N., Proc. NSTI Nanotech 2, 28-31 (2007).



A peptidomimetic siRNA transfection reagent for highly effective gene silencing.
Utku, Y.; Dehan, E.; Ouerfelli, O.; Piano, F.; Zuckermann, R.N.; Pagano, M.; Kirshenbaum, K. Mol. BioSyst. 2, 312-317 (2006)

64. A Threaded Loop Conformation Adopted by a Family of Peptoid Nonamers.
Huang, K.; Wu, C. W.; Sanborn, T. J.; Patch, J. A.; Kirshenbaum, K.; Zuckermann, R. N.; Barron, A. E.; Radhakrishnan, I., J. Am. Chem. Soc. 128, 1733-1738 (2006).
63. A Cleavable Hydrophilic Linker for One-Bead-One-Compound Sequencing of Oligomer Libraries by Tandem Mass Spectrometry.
Paulick, M. G.; Hart, K. M.; Brinner, K. M.; Tjandra, M.; Charych, D. H.; Zuckermann, R. N., J. Comb. Chem. 8, 417-426 (2006).

Chiron Corporation (1989 - 2005)



Synthesis of Long Non-natural Sequence-Specific Heteropolymers.
Lee, B.-C., Dill, K.A. & Zuckermann, R.N. Polymer Preprints 46, 174-175 (2005).



Folding a Nonbiological Polymer into a Compact Multihelical Structure.
Lee, B.-C., Zuckermann, R.N. & Dill, K.A. J. Am. Chem. Soc. 127,10999-11009 (2005). Supporting Info.



Incorporation of Chemoselective Functionalities into Peptoids via Solid-Phase Submonomer Synthesis.
Horn, T., Lee, B.-C., Dill, K.A. & Zuckermann, R.N. Bioconj. Chem. 15, 428-435 (2004).



Versatile Oligo(N-Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery
Patch, J.A., Kirshenbaum, K., Seurynck, S.L., Zuckermann, R.N. & Barron, A.E. in Pseudo-Peptides in Drug Discovery (ed. Nielsen, P.E.) 1-31 (Wiley-VCH, Weinheim, 2004).



Incorporation of Unprotected Heterocyclic Side Chains into Peptoid Oligomers via Solid-Phase Submonomer Synthesis.
Burkoth, T.S., Fafarman, A.T., Charych, D.H., Connolly, M.D. & Zuckermann, R.N. J. Am. Chem. Soc. 125, 8841-8845 (2003).



Structure/Function Analysis of Peptoid/Lipitoid: DNA Complexes.
Lobo, B.A., Vetro, J.A., Suich, D.M., Zuckermann, R.N. & Middaugh, R.C. J. Pharm. Sci. 92, 1905-1918 (2003).



Structural and Spectroscopic Studies of Peptoid Oligomers with alpha-Chiral Aliphatic Side Chains.
Wu, C.W., Kirshenbaum, K., Sanborn, T.J., Patch, J.A., Huang, K., Dill, K.A., Zuckermann, R.N. & Barron, A.E. J. Am. Chem. Soc. 125, 13525-13530 (2003).



Toward the Synthesis of Artificial Proteins: The Discovery of an Amphiphilic Helical Peptoid Assembly.
Burkoth, T.S., Beausoleil, E., Kaur, S., Tang, D., Cohen, F.E. & Zuckermann, R.N. Chemistry & Biology 9, 647-654 (2002). Supporting Info.



Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with alpha-chiral side chains.
Sanborn, T.J., Wu, C.W., Zuckermann, R.N. & Barron, A.E. Biopolymers 63, 12-20 (2002).



Influence of Monomer Structural Elements in Hydrophilic Peptoids
Beausoleil, E., Truong, K.T., Kirshenbaum, K. & Zuckermann, R.N. in Innovations and Perspectives in Solid Phase Synthesis and Combinatorial Libraries: Peptides, Proteins and Nucleic Acids (ed. Epton, R.) 239-242 (Mayflower Scientific Press, Kingswinford, UK, 2001).



The Application of Combinatorial Chemistry in Agrochemical Discovery
Kleschick, W.A., Davis, L.N., Dick, M.R., Garlich, J.R., Martin, E.J., Orr, N., Ng, S.C., Pernich, D.J., Unger, S.H., Watson, G.B. & Zuckermann, R.N. in ACS Symp. Ser. N. 774 (eds. Baker, D.R. & Umetsu, N.K.) (American Chemical Society, 2001).



Peptoid Oligomers with alpha-Chiral Side Chains: Sequence Requirements for the Formation of Stable Peptoid Helices.
Wu, C.W., Sanborn, T.J., Huang, K., Zuckermann, R.N. & Barron, A.E. J. Am. Chem. Soc. 123, 6778-6784 (2001). Supporting Info.



Peptoid Oligomers with alpha-Chiral, Aromatic Sidechains:  Effects of Chain Length on Secondary Structure.
Wu, C.W., Sanborn, T.J., Zuckermann, R.N. & Barron, A.E. J. Am. Chem. Soc. 123, 2958-2963 (2001). Supporting Info.



Improving SH3 Domain Ligand Selectivity Using a Non-natural Scaffold.
Nguyen, J.T., Porter, M., Amoui, M., Miller, T.W., Zuckermann, R.N. & Lim, W.A. Chem. Biol. 7, 463-473 (2000).



Bioinspired Polymeric Materials: In-between Proteins and Plastics.
Barron, A.E. & Zuckermann, R.N. Curr. Op. Chem. Biol. 3, 681-687 (1999).



Designing Polymers that Mimic Biomolecules.
Kirshenbaum, K., Zuckermann, R.N. & Dill, K.A. Curr. Opin. Struct. Biol. 9, 530-535 (1999).



New Submonomers for Poly N-Substituted Glycines (Peptoids).
Uno, T., Beausoleil, E., Goldsmith, R.A., Levine, B.H. & Zuckermann, R.N. Tetrahedron Lett. 40, 1475-1478 (1999).



Parallel Personal Comments on "Classical" Papers in Combinatorial Chemistry.
Lebl, M. J. Comb. Chem. 1, 3-24 (1999). See pages 17 - 18.



NMR Determination of the Major Solution Conformation of a Peptoid Pentamer with Chiral Side Chains.
Armand, P., Kirshenbaum, K., Goldsmith, R.A., Farr-Jones, S., Barron, A.E., Truong, K.T.V., Dill, K.A., Mierke, D.F., Cohen, F.E., Zuckermann, R.N. & Bradley, E.K. Proc. Natl. Acad. Sci. U. S. A. 95, 4309-4314 (1998).



Lipitoids - novel cationic lipids for cellular delivery of plasmid DNA in vitro.
Huang, C.-Y., Uno, T., Murphy, J.E., Lee, S., Hamer, J.D., Escobedo, J.A., Cohen, F.E., Radhakrishnan, R., Dwarki, V. & Zuckermann, R.N. Chem. Biol. 5, 345-354 (1998).



Sequence-Specific Polypeptoids:  A Diverse Family of Heteropolymers with Stable Secondary Structure.
Kirshenbaum, K., Barron, A.E., Goldsmith, R.A., Armand, P., Bradley, E.K., Truong, K.T.V., Dill, K.A., Cohen, F.E. & Zuckermann, R.N. Proc. Natl. Acad. Sci. U. S. A. 95, 4303-4308 (1998).



A Combinatorial Approach to the Discovery of Efficient Cationic Peptoid Reagents for Gene Delivery.
Murphy, J.E., Uno, T., Hamer, J.D., Cohen, F.E., Dwarki, V. & Zuckermann, R.N. Proc. Natl. Acad. Sci. U. S. A. 95, 1517-1522 (1998).



Exploiting the Basis of Proline Recognition by SH3 and WW Domains:  Design of N-Substituted Inhibitors.
Nguyen, J.T., Turck, C.W., Cohen, F.E., Zuckermann, R.N. & Lim, W.A. Science 282, 2088-2092 (1998).



Chiral N-Substituted Glycines Can Form Stable Helical Conformations.
Armand, P., Kirshenbaum, K., Falicov, A., Jr., R.L.D., Dill, K.A., Zuckermann, R.N. & Cohen, F.E. Folding Des. 2, 369-375 (1997).

38. NMR Structural Characterization of Oligo-N-substituted Glycine Lead Compounds from a Combinatorial Library.
Bradley, E.K., Kerr, J.M., Richter, L.S., Figliozzi, G.M., Goff, D.A., Zuckermann, R.N., Spellmeyer, D.C. & Blaney, J.M. Mol. Diversity 3, 1-15 (1997).



Developing a General Strategy for the Solid Supported Synthesis of Heterocycles: Applications to the Generation of Molecular Diversity and Drug Discovery.
Nuss, J.M., Desai, M.C., Zuckermann, R.N., Singh, R., Renhowe, P.A., Goff, D.A., Chinn, J.P., Wang, L., Dorr, H., Brown, E.G. & Subrumanian, S. Pure Appl. Chem. 69 (1997).



Submonomer Approaches for the Generation of Molecular Diversity: Non-natural Oligomer and Organic Template Libraries
Richter, L.S., Goff, D.A., Spear, K.S., Martin, E.J. & Zuckermann, R.N. in Combinatorial Chemistry and Molecular Diversity in Drug Discovery (eds. Gordon, E.M. & Kerwin, J.F.) 151-163 (Wiley-Liss, New York, 1997).



Accelerating Drug Discovery by High-Throughput Combinatorial Synthesis.
Banville, S.C. & Zuckermann, R.N. ISLAR '96 Proceedings, 77-92 (1996).



Synthesis of N-(substituted)glycine Peptoid Libraries.
Figliozzi, G.M., Goldsmith, R., Ng, S., Banville, S.C. & Zuckermann, R.N. Methods Enzymol. 267, 437-447 (1996).



Pharmacologic Characterization of CHIR 2279, an N-Substituted Glycine Peptoid with High-Affinity Binding for alpha1-Adrenoreceptors.
Gibbons, J.A. et al. J. Pharm. Exp. Ther. 277, 885-899 (1996).



The Synthesis of 2-Oxopiperazines by Intramolecular Michael Addition on Solid Support.
Goff, D.A. & Zuckermann, R.N. Tetrahedron Lett. 37, 6247-6250 (1996).



Automated Synthesis of Non-Natural Oligomer Libraries: The Peptoid Concept
Richter, L.S., Spellmeyer, D.C., Martin, E.J., Figliozzi, G.M. & Zuckermann, R.N. in Peptide and Nonpeptide Libraries (ed. Jung, G.) 387-404 (VCH Publishers, Weinheim, 1996).



Solid-Phase Synthesis of Defined 1,4-Benzodiazepine-2,5-dione Mixtures.
Goff, D.A. & Zuckermann, R.N. J. Org. Chem. 60, 5744-5745 (1995).



Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones.
Goff, D.A. & Zuckermann, R.N. J. Org. Chem. 60, 5748-5749 (1995).



Comparison of the Proteolytic Susceptibilities of Homologous L-Amino Acid, D-Amino Acid, and N-Substituted Glycine Peptide and Peptoid Oligomers.
Miller, S.M., Simon, R.J., Ng, S., Zuckermann, R.N., Kerr, J.M. & Moos, W.H. Drug Dev. Res. 35, 20-32 (1995).



Synthesis of Peptide Nucleic Acids (PNA) by Submonomer Solid Phase Synthesis.
Richter, L.S. & Zuckermann, R.N. Bioorg. Med. Chem. Lett 5, 1159-1162 (1995).



Recent Advances in the Generation of Chemical Diversity Libraries.
Desai, M.C., Zuckermann, R.N. & Moos, W.H. Drug Devel. Res. 33, 174-188 (1994).



Free C-terminal Resin-bound Peptides: Reversal of Peptide Orientation via a Cyclization/Cleavage Protocol.
Kania, R.S., Zuckermann, R.N. & Marlowe, C.K. J. Am. Chem. Soc. 116, 8835-8836 (1994).



Proteolytic Studies of Homologous peptide and N-Substituted Glycine Peptoid Oligomers.
Miller, S.M., Simon, R.J., Ng, S., Zuckermann, R.N., Kerr, J.M. & Moos, W.H. Bioorg. Med. Chem. Lett. 4, 2657-2662 (1994).



Using Peptoid Libraries [Poly N-Substituted Glycines] for Drug Discovery.
Simon, R.J., Martin, E.J., Miller, S.M., Zuckermann, R.N., Blaney, J.M. & Moos, W.H. Techniques in Protein Chemistry V, 533-539 (1994).



Automated Tools for the Production of Non-Natural Molecular Diversity
Zuckermann, R.N., Figliozzi, G.M., Banville, S.C., Kerr, J.M., Siani, M.A., Martin, E.J., Brown, E.G. & Wang, L. in Innovations and Perspectives in Solid-Phase Synthesis (ed. Epton, R.) 397-402 (Mayflower Worldwide Ltd., Oxford, 1994).



Synthesis of (N-Substituted)Glycine Polymers of Defined Length and Sequence.
Zuckermann, R.N. & Goff, D.A. Polymer Preprints 35, 975-976 (1994).



Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein Coupled Receptors from a Diverse (N-Substituted)Glycine Peptoid Library.
Zuckermann, R.N. et al. J. Med. Chem. 37, 2678-2685 (1994).



Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids.
Almarsson, Ö., Bruice, T.C., Kerr, J. & Zuckermann, R.N. Proc. Natl. Acad. Sci. U. S. A. 90, 7518-7522 (1993).



Identification of Antibody Mimotopes Containing Non-natural Amino Acids by Recombinant and Synthetic Peptide Library Affinity Selection Methods.
Kerr, J.M., Banville, S.C. & Zuckermann, R.N. Bioorg. Med. Chem. Lett. 3, 405-412 (1993).



Encoded Combinatorial Peptide Libraries Containing Non-natural Amino Acids.
Kerr, J.M., Banville, S.C. & Zuckermann, R.N. J. Am. Chem. Soc. 115, 2529-2531 (1993).



The Chemical Synthesis of Peptidomimetic Libraries.
Zuckermann, R.N. Curr. Opin. Struct. Biol. 3, 580-584 (1993).



Automated Tools for Drug Discovery: Robotic Equimolar Peptide Mixture Synthesis.
Banville, S.C., Kerr, J.M., Siani, M.A. & Zuckermann, R.N. Proceedings of the International Symposium on Laboratory Automation and Robotics, 429-442 (1992).



Simplified Methods for Construction, Assessment and Rapid Screening of Peptide Libraries in Bacteriophage.
Christian, R.B., Zuckermann, R.N., Kerr, J.M., Wang, L. & Malcolm, B.A. J. Mol. Biol. 227, 711-718 (1992).



Peptoids:  A Modular Approach to Drug Discovery.
Simon, R.J. et al. Proc. Natl. Acad. Sci. U. S. A. 89, 9367-9371 (1992).



Automated Peptide-Resin Deprotection/Cleavage by a Robotic Workstation.
Zuckermann, R.N. & Banville, S.C. Pept. Res. 5, 169-174 (1992).



Efficient Method for the Preparation of Peptoids [Oligo(N-substituted glycines)] by Submonomer Solid Phase Synthesis.
Zuckermann, R.N., Kerr, J.M., Kent, S.B.H. & Moos, W.H. J. Am. Chem. Soc. 114, 10646-10647 (1992).



Identification of Highest-Affinity Ligands by Affinity Selection from Equimolar Peptide Mixtures Generated by Robotic Synthesis.
Zuckermann, R.N., Kerr, J.M., Siani, M.A., Banville, S.C. & Santi, D.V. Proc. Natl. Acad. Sci. U. S. A. 89, 4505-4509 (1992).



Control of the Zymate Robot with an External Computer: Construction of a Multiple Peptide Synthesizer.
Zuckermann, R.N., Siani, M.A. & Banville, S.C. Lab. Rob. Autom. 4, 183-192 (1992).



Construction and Application of a Fully Automated Equimolar Peptide Mixture Synthesizer.
Zuckermann, R.N., Siani, M.A. & Banville, S.C. Design, In. J. Pept. Protein Res. 40, 498-507 (1992).

UC Berkeley (1984 - 1989)



Hybrid Enzymes and the Sequence-Specific Cleavage of Nucleic Acids
Corey, D.R., Zuckermann, R.N. & Schultz, P.G. in Bioorganic Chemistry Frontiers (ed. Dugas, H.) 1-31 (Springer-Verlag, Berlin, 1991).



Site-Selective Cleavage of Structured RNA by a Staphylococcal Nuclease-DNA Hybrid.
Zuckermann, R.N. & Schultz, P.G. Proc. Natl. Acad. Sci. U. S. A. 86, 1766-1770 (1989).



Site-Selective Cleavage of RNA by a Hybrid Enzyme.
Zuckermann, R.N., Corey, D.R. & Schultz, P.G. J. Am. Chem. Soc. 110, 1614-1615 (1988).



A Hybrid Sequence-Selective Ribonuclease S.
Zuckermann, R.N. & Schultz, P.G. J. Am. Chem. Soc. 110, 6592-6594 (1988).



Efficient Methods for Attachment of Thiol-Specific Probes to the 3'-end of Synthetic Oligodeoxyribonucleotides.
Zuckermann, R., Corey, D. & Schultz, P. Nucleic Acids Res. 15, 5305-5321 (1987).

Harvey Mudd College (1980 - 1984)



A Synthesis of 2-Fluoro-2-alkenes.
Daub, G.W., Zuckermann, R.N. & Johnson, W.S. J. Org. Chem. 50, 1599-1602 (1985).

Brookhaven National Laboratory (1983)



Dynamic Cis-Trans Isomerization of Retinal in Dark-Adapted Bacteriorhodopsin.
Seltzer, S. & Zuckermann, R. J. Am. Chem. Soc. 107, 5523-5525 (1985).

Back to top